5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

Base Information

Chemical Name:5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide
CAS No.:800402-01-1
Molecular Formula:C₂₃H₃₀ClN₃O₃Si
Molecular Weight:460.048
Hs Code.:

Synonyms:5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

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Chemical Property of 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

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Technology Process of 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

There total 7 articles about 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 800401-68-7
5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

: 131472-79-2
(1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol

: 800402-01-1
5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;

Reference yield:

: 351227-42-4
6-chloro-4-iodopyridin-3-amine

: 800402-01-1
5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / DMF (N,N-dimethyl-formamide) / 21 h / 20 - 107 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); 1: Heck Reaction;

Reference yield:

: 23056-33-9
2-chloro-4-methyl-5-nitro-pyridine

: 800402-01-1
5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium ethoxide / diethyl ether; ethanol / 0.5 h / 20 °C

1.2: 15 h / 20 °C

2.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 2 h / Heating / reflux

3.1: sodium hydroxide; water / ethanol / 2 h / Heating / reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

With sodium hydroxide; potassium ethoxide; water; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); diethyl ether; ethanol; water;