2-Ethoxy-1-naphthoyl Chloride

Base Information

• Chemical Name: 2-Ethoxy-1-naphthoyl Chloride
• CAS No.: 55150-29-3
• Molecular Formula: C13H11ClO2
• Molecular Weight: 234.682
• Hs Code.: 29163990
• European Community (EC) Number: 259-502-5
• DSSTox Substance ID: DTXSID4069002
• Nikkaji Number: J326.746F
• Wikidata: Q72471836
• Mol file: 55150-29-3.mol

Synonyms:2-Ethoxy-1-naphthoyl Chloride;55150-29-3;2-Ethoxynaphthalene-1-carbonyl chloride;1-Naphthalenecarbonyl chloride, 2-ethoxy-;2-Ethoxy-1-naphthoylchloride;EINECS 259-502-5;C13H11ClO2;2-Ethoxy-1-naphthalenecarbonyl chloride;2-ethoxy naphthoyl chloride;SCHEMBL627877;DTXSID4069002;BCP19159;STR04416;MFCD00046426;AKOS005207289;2-Ethoxy-naphthalene-1-carbonyl chloride;CS-0327001;FT-0612197;W-105584

Chemical Property of 2-Ethoxy-1-naphthoyl Chloride

Chemical Property:

• Appearance/Colour: powder
• Vapor Pressure: 7.27E-06mmHg at 25°C
• Melting Point: 76-80 °C
• Refractive Index: 1.605
• Boiling Point: 376.4 °C at 760 mmHg
• Flash Point: 138.5 °C
• PSA: 26.30000
• Density: 1.232 g/cm³
• LogP: 3.61750
• Sensitive.: Moisture Sensitive
• Water Solubility.: 54.75mg/L at 25℃
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 234.0447573
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

99.9% ^*data from raw suppliers

2-Ethoxy-1-naphthoylchloride 97% ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C2=CC=CC=C2C=C1)C(=O)Cl

Technology Process of 2-Ethoxy-1-naphthoyl Chloride

There total 1 articles about 2-Ethoxy-1-naphthoyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxy-1-naphthaloic acid (2224-00-2) → 2-ethoxynaphthalenyl-1-carbonyl chloride (55150-29-3)

Guidance literature:

With thionyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1039/b617888j

Reference yield: 90.0%

2-ethoxynaphthalenyl-1-carbonyl chloride (55150-29-3) + m-cyanoaniline (2237-30-1) → N-(3′-cyanophenyl)-2-ethoxy-1-naphthamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0036-1588517

Reference yield: 88.0%

2-ethoxynaphthalenyl-1-carbonyl chloride (55150-29-3) + 4-Aminobenzonitrile (873-74-5) → N-(4′-cyanophenyl)-2-ethoxy-1-naphthamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0036-1588517

upstream raw materials:

2-ethoxy-1-naphthaloic acid

Downstream raw materials:

naphcillin

(3-Bromo-pyrrolo[2,3-b]pyridin-1-yl)-(2-ethoxy-naphthalen-1-yl)-methanone

(+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-(2-etoxynaphtalene-1-carbonylamino)ethaneboronate

2-(4-methoxyphenyl)benzofuran-4-yl 2-ethoxy-1-naphthoate

Refernces

• 1、 -. "ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF". Page/Page column 22; 43. . Retrieved 2021/06/22.
• 2、 Sakamoto, Masami,Unosawa, Atsushi,Kobaru, Shuichiro,Hasegawa, Yasuhiro,Mino, Takashi,Kasashima, Yoshio,Fujita, Tsutomu. "Diastereoselective photocycloaddition using memory effect of molecular chirality controlled by crystallization". . p. 1632 - 1634. Retrieved 2008/02/10.