(+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

Base Information

Chemical Name:(+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline
CAS No.:212568-45-1
Molecular Formula:C₁₇H₁₈BrNO₂S
Molecular Weight:380.305
Hs Code.:

Synonyms:(+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

Chemical Property:

Purity/Quality:

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Technology Process of (+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

There total 7 articles about (+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 212568-43-9
(-)-(3R)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

: 98-58-8
4-bromobenzenesulfonyl chloride

: 212568-45-1
(+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 60 ℃; for 0.75h;

Reference yield:

: 20668-26-2
3,6-dimethylquinoline

: 212568-45-1
(+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 3 - 20 °C

2: hydrogenchloride / diethyl ether / 2 h / Cooling

3: water / 5 - 60 °C

4: ammonia / water / 5 - 60 °C / pH 11

5: N-ethyl-N,N-diisopropylamine / ethanol / 0.75 h / 60 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethanol; water;

Reference yield:

: 212568-42-8
(+/-)-1,2,3,4-tetrahydro-3,6-dimethylquinolinium hydrochloride

: 212568-45-1
(+)-(3R)-N-(4-bromobenzenesulfonyl)-1,2,3,4-tetrahydro-3,6-dimethylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: water / 5 - 60 °C

2: ammonia / water / 5 - 60 °C / pH 11

3: N-ethyl-N,N-diisopropylamine / ethanol / 0.75 h / 60 °C

With ammonia; N-ethyl-N,N-diisopropylamine; In ethanol; water;