2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

Base Information

Chemical Name:2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene
CAS No.:452100-81-1
Molecular Formula:C₁₈H₂₄N₂O₄S
Molecular Weight:364.466
Hs Code.:

Synonyms:2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

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Chemical Property of 2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

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Technology Process of 2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

There total 3 articles about 2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 3173-56-6
benzyl isothiocyanate

: 5-((R)-4-Amino-3-oxo-tetrahydro-thiophen-2-yl)-pentanoic acid methyl ester; hydrochloride

: 452100-81-1
2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

: (3aR,4R,6aR)-hexahydro-3-benzyl-3a-hydroxy-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 25 ℃; for 2.5h;
DOI:10.1021/jo025794+

Reference yield:

: 449729-42-4
(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-hydroxy-6-oxoheptanoic acid methyl ester

: 452100-81-1
2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate / 2 h / 25 °C

2: 57 percent / triethylamine / tetrahydrofuran / 2.5 h / 25 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo025794+

Reference yield:

: (2R,4R)-4-(6-Carboxy-2-oxo-1-trimethylsilanyloxy-hexyl)-2-phenyl-thiazolidine-3-carboxylic acid tert-butyl ester

: 452100-81-1
2-{4-(methoxycarbonyl)butyl}-4-(3-benzylureido)-3-oxotetrahydrothiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 10percent aqueous citric acid / dibutyl ether; toluene

1.2: 37.9 g / K₂CO₃ / dimethylformamide / 10 - 25 °C

2.1: HCl / ethyl acetate / 2 h / 25 °C

3.1: 57 percent / triethylamine / tetrahydrofuran / 2.5 h / 25 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; dibutyl ether; ethyl acetate; toluene;
DOI:10.1021/jo025794+