(3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate

Base Information

Chemical Name:(3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate
CAS No.:1010805-36-3
Molecular Formula:C₁₈H₂₅NO₆
Molecular Weight:351.4
Hs Code.:

Synonyms:(3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate

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Chemical Property of (3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate

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Technology Process of (3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate

There total 2 articles about (3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 609-02-9
methyl-malonic acid dimethylester

: 150884-50-7
benzaldehyde N-boc imine

: 1010805-36-3
(3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate

Guidance literature:: methyl-malonic acid dimethylester; C₃₅H₂₄N₂Ni₂O₄; In tetrahydrofuran; at 20 ℃; for 0.25h;

benzaldehyde N-boc imine; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

: 609-02-9
methyl-malonic acid dimethylester

: 150884-50-7
benzaldehyde N-boc imine

: 1010805-36-3
(3R)-tert-butyl 3-(tert-butoxycarbonylamino)-2-methoxycarbonyl-2-methyl-3-phenylpropanoate

: (S)-dimethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-methylmalonate

Guidance literature:: With potassium fluoride; benzyl((2S,3S)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-3-methylpentyl)diphenylphosphonium bromide; In toluene; at 0 ℃; for 20h; Overall yield = 99 %; enantioselective reaction;
DOI:10.1016/j.tet.2018.12.052