(S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate
CAS No.:1415757-74-2
Molecular Formula:C₁₉H₂₃FN₄O₄
Molecular Weight:390.414
Hs Code.:

Synonyms:(S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

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Chemical Property of (S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

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Technology Process of (S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

There total 4 articles about (S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 37718-11-9
1H-pyrazole-4-carboxylic acid

: 1415757-62-8
(-)-(S)-2-(4-amino-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester

: 1415757-74-2
(S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 0 - 50 ℃; for 4h;

Reference yield:

: 1415757-61-7
(RS)-2-(4-amino-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester

: 1415757-74-2
(S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

2: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 4 h / 0 - 50 °C

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; n-heptane; isopropyl alcohol;

Reference yield:

: 1400997-78-5
(RS)-[2-(4-bromo-2-fluorophenyl)-2-hydroxyethyl]-(2-hydroxyethyl)carbamic acid tertbutyl ester

: 1415757-74-2
(S)-tert-butyl 2-(2-fluoro-4-(1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tert-butyl methyl ether / 20 °C / Inert atmosphere; Cooling with ice

2: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 4 h / 0 - 50 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; n-heptane; tert-butyl methyl ether; isopropyl alcohol;