(+)-Mefloquine

Base Information

Chemical Name:(+)-Mefloquine
CAS No.:51688-68-7
Molecular Formula:C₁₇H₁₆F₆N₂O
Molecular Weight:378.317
Hs Code.:
DSSTox Substance ID:DTXSID60199641
Nikkaji Number:J238.631C
Wikipedia:Mefloquine
Wikidata:Q27132723
NCI Thesaurus Code:C61827
RXCUI:6694
Pharos Ligand ID:HLV4H4C89PMR
Metabolomics Workbench ID:62892
ChEMBL ID:CHEMBL411329
Mol file:51688-68-7.mol

Synonyms:Lariam;Mefloquine;Mefloquine Hydrochloride;Mephloquine;Ro 21 5998 001;Ro-21-5998-001;Ro215998001;WR 142,490;WR 177,602;WR-142,490;WR-177,602;WR142,490;WR177,602

Suppliers and Price of (+)-Mefloquine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (+)-Mefloquine

Chemical Property:

PSA：45.15000
LogP:4.77670
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:378.11668211
Heavy Atom Count:26
Complexity:483

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antimalarial Agents
Canonical SMILES:C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
Isomeric SMILES:C1CCN[C@@H](C1)[C@@H](C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
Recent ClinicalTrials:Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy
Recent EU Clinical Trials:Pilot study to evaluate the efficacy and safety of mefloquine as prophylaxis in people exposed to the disease caused by the SARS-CoV-2 coronavirus (COVID-19)
Recent NIPH Clinical Trials:The efficacy and safety of mefloquine in patients with progressive multifocal leukoencephalopathy

Technology Process of (+)-Mefloquine

There total 25 articles about (+)-Mefloquine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%