1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride

Base Information

• Chemical Name: 1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride
• CAS No.: 1242030-11-0
• Molecular Formula: C₁₈H₁₇N₅O₂*ClH
• Molecular Weight: 371.826
• Mol file: 1242030-11-0.mol

Synonyms:1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride

Chemical Property of 1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride

There total 1 articles about 1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-amino-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrido[3,2-b]-indole-3-carbonitrile (1242030-09-6) → 1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride (1242030-11-0)

Guidance literature:

2-amino-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrido[3,2-b]-indole-3-carbonitrile; With sodium cyanoborohydride; In methanol; Inert atmosphere;

With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 18h;

DOI:10.1007/s11172-009-0068-5

Reference yield: 99.0%

1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride (1242030-11-0) + acetic anhydride (108-24-7) → N-{[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido[3,2-b]indol-3-yl]methyl}acetamide (1242030-14-3)

Guidance literature:

In benzene; for 4h; Reflux;

DOI:10.1007/s11172-009-0068-5

Reference yield: 93.0%

1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine hydrochloride (1242030-11-0) → 1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine (1242030-10-9)

Guidance literature:

With ammonia; In water;

DOI:10.1007/s11172-009-0068-5

upstream raw materials:

2-amino-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrido[3,2-b]-indole-3-carbonitrile

Downstream raw materials:

1-[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido-[3,2-b]indol-3-yl]methaneamine

N-{[2-imino-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido[3,2-b]indol-3-yl]methyl}acetamide

2-(diacetylaminomethyl)-3-{3-[(4-nitrophenyl)amino]-1H-indol-2-yl}acrylonitrile