ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

Base Information

Chemical Name:ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate
CAS No.:876296-05-8
Molecular Formula:C₂₃H₂₅F₄NO₄
Molecular Weight:455.449
Hs Code.:

Synonyms:ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

Chemical Property:

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Technology Process of ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

There total 4 articles about ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 239087-05-9
2-fluoro-4-(trifluoromethyl)benzylamine

: 311770-42-0
ethyl 3-(3-carboxy-4-methoxyphenyl)-2-ethylpropanoate

: 876296-05-8
ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

Guidance literature:: With TEA; chloroformic acid ethyl ester; In dichloromethane;
DOI:10.1016/j.bmcl.2005.10.049

Reference yield:

: 17145-91-4
triethyl 2-ethylphosphonoacetate

: 876296-05-8
ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran

2: H₂ / Pd/C / ethanol

3: ClCO₂Et; TEA / CH₂Cl₂

With TEA; hydrogen; chloroformic acid ethyl ester; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.10.049

Reference yield:

: 311770-43-1
ethyl (3-benzyloxycarbonyl-4-methoxyphenyl)-2-ethylacrylate

: 876296-05-8
ethyl 2-ethyl-3-[4-methoxy-3-[N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: ClCO₂Et; TEA / CH₂Cl₂

With TEA; hydrogen; chloroformic acid ethyl ester; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.10.049