4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Chemical Name:4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid
CAS No.:1561958-49-3
Molecular Formula:C₃₀H₄₁ClF₃N₃O₅S
Molecular Weight:648.187
Hs Code.:

4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Synonyms:4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Chemical Property of 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Technology Process of 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

There total 9 articles about 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951160-35-3
methyl 4-amino-2,2-dimethylbutanoate hydrochloride

: 1561964-79-1
1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxylic acid

: 1561958-49-3
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: methyl 4-amino-2,2-dimethylbutanoate hydrochloride; 1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxylic acid;

With water; potassium hydroxide; In ethanol;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561958-49-3
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 30 °C

2.1: tetrahydrofuran / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

5.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

6.1: N-chloro-succinimide / tetrahydrofuran / 2 h / -78 - 20 °C

7.1: potassium tert-butylate; water / dimethyl sulfoxide / 1 h / 90 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; N-chloro-succinimide; copper(l) iodide; ammonium cerium (IV) nitrate; potassium tert-butylate; water; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1561964-36-0
ethyl 5-formyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561958-49-3
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-chloro-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 0 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

4.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

5.1: N-chloro-succinimide / tetrahydrofuran / 2 h / -78 - 20 °C

6.1: potassium tert-butylate; water / dimethyl sulfoxide / 1 h / 90 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; N-chloro-succinimide; copper(l) iodide; ammonium cerium (IV) nitrate; potassium tert-butylate; water; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;