(2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester

Base Information Edit

Chemical Name:(2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester
CAS No.:260408-10-4
Molecular Formula:C₂₀H₂₂O₅S
Molecular Weight:374.458
Hs Code.:
Mol file:260408-10-4.mol

Synonyms:(2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester

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Chemical Property of (2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester Edit

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Technology Process of (2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester

There total 8 articles about (2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 260408-09-1
(2S)-hydroxysuccinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester

: 5188-07-8
sodium thiomethoxide

: 260408-10-4
(2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester

Guidance literature:: (2S)-hydroxysuccinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester; With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 ℃; for 4h;

sodium thiomethoxide; With 15-crown-5; In dichloromethane; N,N-dimethyl-formamide; at -78 - 20 ℃; Further stages.;
DOI:10.1021/ja003770j

Reference yield:

: 66178-04-9
(S)-3-(Benzyloxycarbonyl)-3-hydroxypropanoic acid

: 260408-10-4
(2R)-methanesulfanyl-succinic acid-1-benzyl ester-4-(4-methoxybenzyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₃CO₃ / dimethylformamide / 96 h / 20 °C

2.1: 2,6-lutidine; triflic anhydride / CH₂Cl₂ / 4 h / -78 °C

2.2: 15-crown-5 / CH₂Cl₂; dimethylformamide / -78 - 20 °C

With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja003770j