Technology Process of Fmoc-β(2)hGln(Trt)-OH
There total 7 articles about Fmoc-β(2)hGln(Trt)-OH which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide / N,N-dimethyl-formamide / 0.67 h / 20 °C
1.2: 30 h / 60 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C
3.1: palladium on activated carbon; palladium hydroxide, 20 wt% on carbon; ammonium formate / ethanol / 7 h / 60 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
5.1: dichromic acid / acetonitrile; water / 2 h / 20 °C
With
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; palladium hydroxide, 20 wt% on carbon; palladium on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; dichromic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
5.1: |Jones Oxidation;
DOI:10.1021/acs.joc.9b02562
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / methanol; water; tetrahydrofuran / 8 h / 20 °C
2.1: triethylamine; N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide / N,N-dimethyl-formamide / 0.67 h / 20 °C
2.2: 30 h / 60 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C
4.1: palladium on activated carbon; palladium hydroxide, 20 wt% on carbon; ammonium formate / ethanol / 7 h / 60 °C / Inert atmosphere
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
6.1: dichromic acid / acetonitrile; water / 2 h / 20 °C
With
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; palladium hydroxide, 20 wt% on carbon; palladium on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; dichromic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
6.1: |Jones Oxidation;
DOI:10.1021/acs.joc.9b02562
