N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide

Base Information

• Chemical Name: N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
• CAS No.: 1424430-92-1
• Molecular Formula: C₂₅H₂₅ClN₄OS
• Molecular Weight: 465.019
• Mol file: 1424430-92-1.mol

Synonyms:N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide

Chemical Property of N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide

There total 1 articles about N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C19H21IN4O (1321913-85-2) + p-Chlorothiophenol (106-54-7) → N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide (1424430-92-1)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmc.2012.12.029

Reference yield: 51.0%

N-[7-benzyl-5-((4-chlorophenyl)sulfanyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide (1424430-92-1) → C20H17ClN4S (1424430-61-4)

Guidance literature:

With sodium hydroxide; In methanol; water; for 12h; Reflux;

DOI:10.1016/j.bmc.2012.12.029

upstream raw materials:

C₁₉H₂₁IN₄O

p-Chlorothiophenol

Downstream raw materials:

C₂₀H₁₇ClN₄S