4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

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Chemical Name:4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate
CAS No.:1339035-72-1
Molecular Formula:C₂₇H₁₉ClF₃N₅O₂
Molecular Weight:537.928
Hs Code.:

Synonyms:4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

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Chemical Property of 4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

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Technology Process of 4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

There total 3 articles about 4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 23351-09-9
4-(1H-pyrrol-1-yl)phenol

: 1254703-67-7
C₁₇H₁₂ClF₃N₄O₂

: 1339035-72-1
4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 1254703-86-0
C₁₃H₁₁F₃O₄

: 1339035-72-1
4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1339035-72-1
4-(1H-pyrrol-1-yl)phenyl 3-{1-(6-chloropyridazin-3-yl)-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: Alkaline conditions

2: triethylamine / methanol / Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009