(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

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Chemical Name:(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid
CAS No.:887601-32-3
Molecular Formula:C₄₅H₇₅N₅O₁₂
Molecular Weight:878.117
Hs Code.:

(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

Synonyms:(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

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Chemical Property of (S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

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Technology Process of (S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

There total 4 articles about (S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid allyl ester

: 887601-32-3
(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 308279-72-3
N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-L-allothreonine

: 887601-32-3
(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N; 1-hydroxybenzotriazole; EDCI*HCl / CH₂Cl₂ / 0 - 20 °C

2: 99 percent / H₂ / Pd/C / ethanol / 20 °C

3: 100 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

4: TBAF; AcOH / tetrahydrofuran / 18 h / 0 - 20 °C

5: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 18 h / 20 °C

With morpholine; dmap; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 694527-65-6
Boc-L-allo-Thr(TBS)-N-Me-Gly-OBn

: 887601-32-3
(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-{2-[((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyryl)-methyl-amino]-acetoxy}-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / ethanol / 20 °C

2: 100 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

3: TBAF; AcOH / tetrahydrofuran / 18 h / 0 - 20 °C

4: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 18 h / 20 °C

With morpholine; dmap; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; acetic acid; diisopropyl-carbodiimide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2003.10.055