19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

Base Information

Chemical Name:19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol
CAS No.:16614-50-9
Molecular Formula:C₃₁H₄₁NO₄
Molecular Weight:491.671
Hs Code.:

19<i>anti</i>-((<i>R</i>)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

Synonyms:19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

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Chemical Property of 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

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Technology Process of 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

There total 3 articles about 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16614-49-6
19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropanecarbonyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

: 16614-50-9
19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1021/ja00989a032

Reference yield:

: 16528-08-8
19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

: 16614-50-9
19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / diethyl ether

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00989a032

Reference yield:

: 16529-94-5
19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-6β,14-ethano-morphin-7-ene-17-carbonitrile

: 16614-50-9
19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-17-cyclopropylmethyl-4,5α-epoxy-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / bis-(2-hydroxy-ethyl) ether / 200 - 220 °C

2: K₂CO₃ / diethyl ether

3: LiAlH₄ / tetrahydrofuran

With potassium hydroxide; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; diethyl ether; diethylene glycol;
DOI:10.1021/ja00989a032