methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate
CAS No.:1445786-42-4
Molecular Formula:C₂₇H₂₇N₅O₆
Molecular Weight:517.541
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

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Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

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Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

There total 4 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

: 1375150-07-4
methyl 3-[(1-methylethyl)oxy]-5-nitrobenzoate

: 1374867-83-0
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

: 1445786-42-4
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

Guidance literature:: methyl 3-[(1-methylethyl)oxy]-5-nitrobenzoate; With palladium 10% on activated carbon; hydrogen; acetic acid; at 20 ℃;

4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide; at 20 ℃;

Reference yield:

: 55076-32-9
methyl 3-hydroxy-5-nitrobenzoate

: 1445786-42-4
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 120 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445786-42-4
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; water;