(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

Base Information

Chemical Name:(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane
CAS No.:165961-49-9
Molecular Formula:C₂₈H₄₂O₃Si
Molecular Weight:454.725
Hs Code.:

Synonyms:(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

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Chemical Property of (4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

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Technology Process of (4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

There total 7 articles about (4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 107-30-2
chloromethyl methyl ether

: 152033-13-1
(3S,4S,5R)-3,5-Dimethyl-8-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-1-octen-4-ol

: 165961-49-9
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 18h;
DOI:10.1021/jo00121a026

Reference yield:

: Ethyl (4R)-5-(tetrahydropyran-2-yloxy)-4-methyl-2-pentenoate

: 165961-49-9
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 6 h / 25 °C

2: LiAlH₄ / diethyl ether / 0.5 h / 25 °C

3: 99 percent / imidazole / dimethylformamide / 18 h / 25 °C

4: 80 percent / p-TsOH*H₂O / methanol / 0.83 h / 25 °C

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) 25 deg C, 30 min

6: BF₃*Et₂O / CH₂Cl₂ / 1.) -86 deg C, 15 min; -86 to -70 deg C, 45 min, 2.) 0 deg C, 1 h

7: 100 percent / i-Pr₂NEt / CH₂Cl₂ / 18 h / 25 °C

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a026

Reference yield:

: 123595-52-8
(2R)-2-Methyl-5-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-1-pentanol

: 165961-49-9
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) 25 deg C, 30 min

2: BF₃*Et₂O / CH₂Cl₂ / 1.) -86 deg C, 15 min; -86 to -70 deg C, 45 min, 2.) 0 deg C, 1 h

3: 100 percent / i-Pr₂NEt / CH₂Cl₂ / 18 h / 25 °C

With oxalyl dichloride; boron trifluoride diethyl etherate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00121a026