5,10-dideazaaminopterin

Base Information

• Chemical Name: 5,10-dideazaaminopterin
• CAS No.: 95674-53-6
• Molecular Formula: C21H22 N6 O5
• Molecular Weight: 0
• Mol file: 95674-53-6.mol

Synonyms:Pyrido[2,3-d]pyrimidine,L-glutamic acid deriv.

Chemical Property of 5,10-dideazaaminopterin

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 194.41000
• Density: 1.474g/cm³
• LogP: 2.57550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,10-dideazaaminopterin

There total 17 articles about 5,10-dideazaaminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate (95674-69-4) → 5,10-dideazaaminopterin (95674-53-6)

Guidance literature:

With sodium hydroxide; In methanol; for 72h; Ambient temperature;

DOI:10.1021/jm00145a012

Reference yield:

diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate (95674-69-4) → 5,10-dideazaaminopterin + 5,10-dideazaaminopterin (95674-53-6)

Guidance literature:

With sodium hydroxide; acetic acid; In methanol;

Reference yield:

2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine (80360-04-9) → 5,10-dideazaaminopterin (95674-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 34.5 percent / sodium hydride, N-methylpyrrolidone / 504 h / Ambient temperature

2: 58 percent / TFA, H₂ / Pd/C / 24 h / 2844.3 Torr

3: 44 percent / 0.5 N NaOH / methanol / 72 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00145a012

upstream raw materials:

diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine

2,4-diamino-6-(4-carboxystyryl)-5-deazapteridine

2,4-diamino-6-<4-(tert-butoxycarbonyl)styryl>-5-deazapteridine

Refernces

• 1、 DeGraw,Tagawa,Christie,et al.. "Synthesis of 5,10-dideazaminopterin". . p. 1 - 4. Retrieved 2007/10/02.