ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

Base Information

Chemical Name:ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate
CAS No.:1539304-14-7
Molecular Formula:C₂₁H₂₉ClN₄O₅SSi
Molecular Weight:513.09
Hs Code.:

Synonyms:ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

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Chemical Property of ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

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Technology Process of ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

There total 10 articles about ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1434589-59-9
ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

: 126328-84-5
tert-butyl (3-(chloromethyl)phenoxy)dimethylsilane

: 1539304-14-7
ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; at 20 ℃; for 16h;

Reference yield:

: 38136-96-8
6-chloro-2-(methylsulfanyl)-5-nitropyrimidin-4-amine

: 1539304-14-7
ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 6 h / 20 °C

2: potassium carbonate; sodium iodide / acetone / 16 h / 20 °C

With potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; acetone;

Reference yield:

: 1979-98-2
4,6-dihydroxy-2-methylmercaptopyrimidine

: 1539304-14-7
ethyl 3-((tert-butyldimethylsilyl)oxy)benzyl(6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 0.5 h / 20 °C

1.2: 5 - 20 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 0 - 100 °C

3.1: triethylamine; ammonia / tetrahydrofuran; isopropyl alcohol / 5 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 6 h / 20 °C

5.1: potassium carbonate; sodium iodide / acetone / 16 h / 20 °C

With ammonia; potassium carbonate; N,N-dimethyl-aniline; triethylamine; trifluoroacetic acid; sodium iodide; trichlorophosphate; In tetrahydrofuran; isopropyl alcohol; acetone;