Indatraline hydrochloride

Base Information

Chemical Name:Indatraline hydrochloride
CAS No.:86939-40-4
Molecular Formula:C₁₆H₁₅Cl₂N*ClH
Molecular Weight:328.669
Hs Code.:

Synonyms:Indatraline hydrochloride

Suppliers and Price of Indatraline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Indatraline hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of Indatraline hydrochloride

There total 8 articles about Indatraline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 86939-10-8
indatraline

: 86939-40-4,96850-13-4
Indatraline hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.044

Reference yield:

: 1422045-78-0
(1R,3S)-1-(benzyloxy)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-indene

: 86939-40-4,96850-13-4
Indatraline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / hexane / 40 h / -40 °C / Inert atmosphere

1.2: 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogen / methanol; dichloromethane / 6 h / 20 °C

4.1: hydrogenchloride / water; diethyl ether / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.12.044

Reference yield:

: 1422045-79-1
benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 86939-40-4,96850-13-4
Indatraline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

2: hydrogen / methanol; dichloromethane / 6 h / 20 °C

3: hydrogenchloride / water; diethyl ether / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.12.044