N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

Base Information

Chemical Name:N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide
CAS No.:1181282-54-1
Molecular Formula:C₂₇H₃₆N₄O
Molecular Weight:432.609
Hs Code.:

Synonyms:N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

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Chemical Property of N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

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Technology Process of N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

There total 7 articles about N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 830-96-6
Indole-3-propionic acid

: N,N-dimethyl-1-(2-(methylamino)ethyl)-4-phenylpiperidine-4-amine tris-hydrochloride

: 1181282-54-1
N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

Guidance literature:: Indole-3-propionic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

N,N-dimethyl-1-(2-(methylamino)ethyl)-4-phenylpiperidine-4-amine tris-hydrochloride; With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 12h;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1181282-54-1
N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / iodine / diethyl ether / 2.58 h

1.2: 80 °C

1.3: 0 °C / Saturated solution

2.1: 20 °C

2.2: 0 °C / Saturated solution

3.1: ethanol; potassium hydroxide / 48 h / Reflux

4.1: sodium cyanoborohydride / methanol / 0 - 20 °C

4.2: 20 °C / pH ~ 5

5.1: hydrogenchloride / chloroform / 1 h

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

6.2: 12 h / 20 °C

With hydrogenchloride; ethanol; sodium cyanoborohydride; magnesium; 1,1'-carbonyldiimidazole; potassium hydroxide; iodine; In methanol; diethyl ether; dichloromethane; chloroform;

Reference yield:

: 92703-36-1
1-benzyl-4-dimethylamino-piperidine-4-carbonitrile

: 1181282-54-1
N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / iodine / diethyl ether / 2.58 h

1.2: 80 °C

1.3: 0 °C / Saturated solution

2.1: 20 °C

2.2: 0 °C / Saturated solution

3.1: ethanol; potassium hydroxide / 48 h / Reflux

4.1: sodium cyanoborohydride / methanol / 0 - 20 °C

4.2: 20 °C / pH ~ 5

5.1: hydrogenchloride / chloroform / 1 h

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

6.2: 12 h / 20 °C

With hydrogenchloride; ethanol; sodium cyanoborohydride; magnesium; 1,1'-carbonyldiimidazole; potassium hydroxide; iodine; In methanol; diethyl ether; dichloromethane; chloroform;