Technology Process of 1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate
There total 5 articles about 1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2,3,4-tetrahydro-1,8-naphthyridine; 1-[(2,5-dichlorophenyl)methoxy]cyclopropane-1-carbonyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
trifluoroacetic acid;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diazomethyl-trimethyl-silane / methanol; diethyl ether; dichloromethane / 0.17 h / 20 °C
1.2: 0.08 h / 20 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
3.1: triethylamine / dichloromethane / 3 h / 20 °C
With
oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; diazomethyl-trimethyl-silane;
In
methanol; diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
2: triethylamine / dichloromethane / 3 h / 20 °C
With
oxalyl dichloride; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane;
