1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

Base Information

Chemical Name:1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate
CAS No.:1445982-34-2
Molecular Formula:C₂HF₃O₂*C₁₉H₁₈Cl₂N₂O₂
Molecular Weight:491.294
Hs Code.:

Synonyms:1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

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Chemical Property of 1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

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Technology Process of 1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

There total 5 articles about 1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 13623-87-5
1,2,3,4-tetrahydro-1,8-naphthyridine

: 1445985-44-3
1-[(2,5-dichlorophenyl)methoxy]cyclopropane-1-carbonyl chloride

: 76-05-1
trifluoroacetic acid

: 1445982-34-2
1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

Guidance literature:: 1,2,3,4-tetrahydro-1,8-naphthyridine; 1-[(2,5-dichlorophenyl)methoxy]cyclopropane-1-carbonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 2745-49-5
1,4-Dichloro-2-chloromethyl-benzene

: 1445982-34-2
1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diazomethyl-trimethyl-silane / methanol; diethyl ether; dichloromethane / 0.17 h / 20 °C

1.2: 0.08 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 3 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; diazomethyl-trimethyl-silane; In methanol; diethyl ether; dichloromethane;

Reference yield:

: 1445984-98-4
1-(2,5-dichlorobenzyloxy)cyclopropanecarboxylic acid

: 1445982-34-2
1-([1-[(2,5-dichlorophenyl)methoxy]cyclopropyl]carbonyl)-1,2,3,4-tetrahydro-1,8-naphthyridine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;