1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

Base Information

Chemical Name:1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone
CAS No.:138155-07-4
Molecular Formula:C₁₈H₂₂Cl₂N₂O₂
Molecular Weight:369.291
Hs Code.:

Synonyms:1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

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Chemical Property of 1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

Chemical Property:

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Technology Process of 1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

There total 5 articles about 1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58481-17-7
methyl 2-(hydroxymethyl)pyridine-4-carboxylate

: 138155-07-4
1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / etheral HCl, SOCl₂ / 4 h / 0 - 20 °C

2: 64 percent / Et₃N / CH₂Cl₂ / 1.) -60 deg C, 1 h, 2.) RT, 72 h

3: 35 percent / H₂ / 5percent Rh/C / ethanol / 14 h / 70 °C / 3620.04 Torr

4: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 40 min, 2.) CH₂Cl₂, RT, 18 h

5: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2 h, 2.) CH₂Cl₂

With hydrogenchloride; thionyl chloride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole; Rh on carbon; In ethanol; dichloromethane;
DOI:10.1021/jm00081a009

Reference yield:

: 125104-37-2
methyl 2-(1-pyrrolidinylmethyl)-4-pyridinecarboxylate

: 138155-07-4
1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / H₂ / 5percent Rh/C / ethanol / 14 h / 70 °C / 3620.04 Torr

2: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 40 min, 2.) CH₂Cl₂, RT, 18 h

3: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2 h, 2.) CH₂Cl₂

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole; Rh on carbon; In ethanol;
DOI:10.1021/jm00081a009

Reference yield:

: 125398-17-6
methyl 2-(chloromethyl)-4-pyridinecarboxylate hydrochloride

: 138155-07-4
1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / Et₃N / CH₂Cl₂ / 1.) -60 deg C, 1 h, 2.) RT, 72 h

2: 35 percent / H₂ / 5percent Rh/C / ethanol / 14 h / 70 °C / 3620.04 Torr

3: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 40 min, 2.) CH₂Cl₂, RT, 18 h

4: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2 h, 2.) CH₂Cl₂

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole; Rh on carbon; In ethanol; dichloromethane;
DOI:10.1021/jm00081a009