((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate

Base Information

• Chemical Name: ((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate
• CAS No.: 1032191-89-1
• Molecular Formula: C₁₈H₂₂F₃NO₄
• Molecular Weight: 373.372
• Mol file: 1032191-89-1.mol

Synonyms:((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate

Chemical Property of ((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate

There total 1 articles about ((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(2Z)-4-(tetrahydropyran-2-yloxy)but-2-en-1-ol (57323-06-5) + N-(4-methoxyphenyl)trifluoroacetimidoyl chloride (75999-66-5) → ((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate (1032191-89-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; paraffin oil; at 0 - 20 ℃;

DOI:10.1002/chem.200701642

Reference yield: 94.0%

((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyl)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidate (1032191-89-1) → 2,2,2-trifluoro-N-(4-methoxyphenyl)-N-((2R)-1-(tetrahydro-2H-pyran-2-yloxy)but-3-en-2-yl)acetamide (1032192-18-9)

Guidance literature:

With bis(di-μ-chloro-μ-{[bis-η⁵-(4'R,5'R)-(S_p)-2-(2'-4',5'-dihydro-4',5'-diphenyl-1'-tosyl-imidazolyl)cyclopentadienyl] iron(II) 1-C,3'-N} dipalladium(II)); silver(I) 4-methylbenzenesulfonate; In chloroform; at 55 ℃; for 72h; optical yield given as %ee; Inert atmosphere; Darkness;

DOI:10.1002/chem.200701642

upstream raw materials:

(2Z)-4-(tetrahydropyran-2-yloxy)but-2-en-1-ol

N-(4-methoxyphenyl)trifluoroacetimidoyl chloride

Downstream raw materials:

2,2,2-trifluoro-N-(4-methoxyphenyl)-N-((2R)-1-(tetrahydro-2H-pyran-2-yloxy)but-3-en-2-yl)acetamide