ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate

Base Information

• Chemical Name: ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate
• CAS No.: 124126-78-9
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 124126-78-9.mol

Synonyms:ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate

Chemical Property of ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate

There total 6 articles about ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.4%

ethyl 2-(carboxymethyl)-1-benzamidocyclopropane-1-carboxylate (124126-77-8) → ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate (124126-78-9)

Guidance literature:

With diborane; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jm00164a056

Reference yield:

diethyl 2-ketoglutarate (5965-53-7) → ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate (124126-78-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 70.4 percent / concd. H₂SO₄ / 7 h / -10 - 5 °C

2: 74.3 percent / p-toluenesulphonic acid / benzene / 120 h / Heating

3: CHCl₃; diethyl ether / 18 h / 5 °C

4: benzene; diethyl ether / Irradiation

5: 62 percent / aq. LiOH / tetrahydrofuran / 1 h / 0 °C

6: 58.4 percent / B₂H₆ / tetrahydrofuran / 0.5 h / 0 °C

With lithium hydroxide; sulfuric acid; toluene-4-sulfonic acid; diborane; In tetrahydrofuran; diethyl ether; chloroform; benzene;

DOI:10.1021/jm00164a056

Reference yield:

diethyl N-benzoyl-α,β-dehydroglutamate (124153-34-0) → ethyl 2-(2-hydroxyethyl)-1-benzamidocyclopropane-1-carboxylate (124126-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1: CHCl₃; diethyl ether / 18 h / 5 °C

2: benzene; diethyl ether / Irradiation

3: 62 percent / aq. LiOH / tetrahydrofuran / 1 h / 0 °C

4: 58.4 percent / B₂H₆ / tetrahydrofuran / 0.5 h / 0 °C

With lithium hydroxide; diborane; In tetrahydrofuran; diethyl ether; chloroform; benzene;

DOI:10.1021/jm00164a056

upstream raw materials:

ethyl 2-(carboxymethyl)-1-benzamidocyclopropane-1-carboxylate

diethyl 2-ketoglutarate

diethyl N-benzoyl-α,β-dehydroglutamate

ethyl 2-(carbethoxymethyl)-1-benzamidocyclopropane-1-carboxylate