N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

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Chemical Name:N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea
CAS No.:1395051-02-1
Molecular Formula:C₂₅H₃₀N₁₀O₂
Molecular Weight:502.579
Hs Code.:

Synonyms:N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

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Chemical Property of N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

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Technology Process of N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

There total 5 articles about N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1391621-82-1
C₂₀H₂₆N₈

: C₁₂H₁₁N₃O₅

: 1395051-02-1
N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

Guidance literature:: With sodium hydrogencarbonate; In dimethyl sulfoxide; at 50 ℃;
DOI:10.1016/j.bmc.2013.03.083

Reference yield:

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 1395051-02-1
N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane / 4 h / 20 - 80 °C

2: pyridine / 2 h / 20 - 80 °C

3: hydrogen; palladium 10% on activated carbon; hydrogenchloride / methanol; water / 12 h / 20 °C

4: sodium hydrogencarbonate / dimethyl sulfoxide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In 1,4-dioxane; pyridine; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.03.083

Reference yield:

: 1391621-73-0,1395051-03-2
C₂₈H₃₂N₈O₂

: 1395051-02-1
N-(5-methyl-3-isoxazolyl)-N'-4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinylamino]-1H-3-pyrazolyl)benzylurea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon; hydrogenchloride / methanol; water / 12 h / 20 °C

2: sodium hydrogencarbonate / dimethyl sulfoxide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.03.083