Ebaresdax

Base Information

Chemical Name:Ebaresdax
CAS No.:1334471-39-4
Molecular Formula:C₁₂H₁₄N₂O₃S
Molecular Weight:266.321
Hs Code.:
UNII:V69IJ95J08
NCI Thesaurus Code:C179081
ChEMBL ID:CHEMBL5095417

Synonyms:Ebaresdax;Ebaresdax [INN];ACP-044;Ebaresdax [USAN];ACP044;V69IJ95J08;Ebaresdax [USAN:INN];1334471-39-4;UNII-V69IJ95J08;WHO 11566;(4R)-2-(2-hydroxyanilino)-5,5-dimethyl-4H-1,3-thiazole-4-carboxylic acid;(4R)-2-(2-Hydroxyanilino)-5,5-dimethyl-4,5-dihydro-1,3- thiazole-4-carboxylic acid;CHEMBL5095417;SCHEMBL11927658;GTPL12149;compound 1 [WO2020159643A1];MS-23765;HY-139569;CS-0213549;(4R)-2-[(2-hydroxphenyl)amino]-5,5-dimethyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid;4-Thiazolecarboxylic acid, 4,5-dihydro-2-[(2-hydroxyphenyl)amino]-5,5-dimethyl-, (4R)-

Suppliers and Price of Ebaresdax

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of Ebaresdax

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:266.07251349
Heavy Atom Count:18
Complexity:370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C(N=C(S1)NC2=CC=CC=C2O)C(=O)O)C
Isomeric SMILES:CC1([C@H](N=C(S1)NC2=CC=CC=C2O)C(=O)O)C

Technology Process of Ebaresdax

There total 4 articles about Ebaresdax which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

: 615-18-9
2-chloro-1,3-benzoxazole

: 1113-41-3
L-penicillamine

: 1334471-39-4
(R)-2-((2-hydroxyphenyl)amino)-5,5-dimethyl-4,5-dihydrothiazole-4-carboxylic acid

Guidance literature:: With water; sodium hydroxide; at 10 - 30 ℃; for 10h; Inert atmosphere;

Reference yield: 64.0%

: (R)-2-((2-methoxyphenyl)amino)-5,5-dimethyl-4,5-dihydrothiazole-4-carboxylic acid

: 1334471-39-4
(R)-2-((2-hydroxyphenyl)amino)-5,5-dimethyl-4,5-dihydrothiazole-4-carboxylic acid

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 1516-37-6
1-(2-methoxyphenyl)thiourea

: 1334471-39-4
(R)-2-((2-hydroxyphenyl)amino)-5,5-dimethyl-4,5-dihydrothiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: di(acetyloxy)iodobenzene; ammonium hydroxide / acetonitrile / 4.17 h / 20 °C / Cooling with ice

2: acetonitrile; water / 2 h / Reflux; Inert atmosphere

3: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

With ammonium hydroxide; di(acetyloxy)iodobenzene; boron tribromide; In dichloromethane; water; acetonitrile;