(2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

Base Information

Chemical Name:(2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol
CAS No.:129269-50-7
Molecular Formula:C₁₉H₃₂O₆
Molecular Weight:356.459
Hs Code.:

Synonyms:(2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

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Chemical Property of (2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

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Technology Process of (2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

There total 9 articles about (2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 129245-09-6,129245-57-4
2,6-didesoxy-3-O-(p-methoxybenzyl)-4-O-methoxymethyl-2,4,6-tri-C-methyl-D-glucopyranose

: 129269-50-7
(2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 50h;
DOI:10.1007/BF00963025

Reference yield:

: 81099-74-3,129269-49-4
(2R,3R,4R,5R)-3,4-Bis-benzyloxy-2-ethyl-6-methoxy-3,5-dimethyl-tetrahydro-pyran

: 129269-50-7
(2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

Guidance literature:: Multi-step reaction with 8 steps

1: EtOH / Raney-Ni / 1 h / Heating

2: PPTS / 5 h / Heating

3: 100 percent / pyridine / 2 h / 50 °C

4: 100 percent / iPr₂NEt / CH₂Cl₂ / 2.5 h / 50 °C

5: 100 percent / 1N MeONa/MeOH / 3 h / 50 °C

6: 1) NaH / 1) DMF, 30 min, 2) 12h

7: 1) t-BuOK, 2) Hg(OAc)2 / 1) DSMO, 50 deg C, 2h, 2) acetone, water, 20 deg C, 12h

8: 100 percent / NaBH₄ / aq. ethanol / 50 h

With pyridine; methanol; sodium tetrahydroborate; ethanol; potassium tert-butylate; mercury(II) diacetate; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; nickel; In ethanol; dichloromethane;
DOI:10.1007/BF00963025

Reference yield:

: 129245-02-9,129245-56-3
(2R,3S,4R,5R)-2-Ethyl-6-methoxy-3,5-dimethyl-tetrahydro-pyran-3,4-diol

: 129269-50-7
(2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-4-methoxymethoxy-2,4-dimethyl-heptane-1,5-diol

Guidance literature:: Multi-step reaction with 7 steps

1: PPTS / 5 h / Heating

2: 100 percent / pyridine / 2 h / 50 °C

3: 100 percent / iPr₂NEt / CH₂Cl₂ / 2.5 h / 50 °C

4: 100 percent / 1N MeONa/MeOH / 3 h / 50 °C

5: 1) NaH / 1) DMF, 30 min, 2) 12h

6: 1) t-BuOK, 2) Hg(OAc)2 / 1) DSMO, 50 deg C, 2h, 2) acetone, water, 20 deg C, 12h

7: 100 percent / NaBH₄ / aq. ethanol / 50 h

With pyridine; methanol; sodium tetrahydroborate; potassium tert-butylate; mercury(II) diacetate; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1007/BF00963025