(E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

Base Information

Chemical Name:(E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol
CAS No.:866367-98-8
Molecular Formula:C₃₂H₅₄O₅
Molecular Weight:518.778
Hs Code.:

Synonyms:(E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

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Chemical Property of (E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

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Technology Process of (E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

There total 8 articles about (E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 866367-88-6
(4R,5S,6R)-4-((E)-(3S,7S,9S)-10-Benzyloxy-3,5,7,9-tetramethyl-dec-4-enyl)-6-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxane

: 866367-98-8
(E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

Guidance literature:: With W-2 Raney nickel; hydrogen; In ethanol; at 20 ℃;
DOI:10.1021/ol051512r

Reference yield:

: 866367-95-5
(E)-(3S,7S,9S)-10-Benzyloxy-3,5,7,9-tetramethyl-dec-4-en-1-ol

: 866367-98-8
(E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine

2.1: dimethylsulfoxide / 70 °C

3.1: 27 mg / DIBAL / toluene; hexane / 0.33 h / -78 °C

4.1: (-)-(Ipc)2BOTf; Et₃N / CH₂Cl₂ / 3 h / 0 °C

4.2: 70 percent / CH₂Cl₂ / 1 h / 0 °C

5.1: Me₄N(OAc)3BH; AcOH / acetonitrile / -20 °C

6.1: 78 mg / pyridinium p-toluenesulfonate / CH₂Cl₂ / 3 h

7.1: 82 percent / H₂; W-2 Raney nickel / ethanol / 20 °C

With pyridine; W-2 Raney nickel; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; acetic acid; (+)-diisopinocampheylborane trifluoromethanesulfonate; triethylamine; tetramethylammonium triacetoxyborohydride; In ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/ol051512r

Reference yield:

: 866367-86-4
(E)-(4S,8S,10S)-11-benzyloxy-4,6,8,10-tetramethylundec-5-enal

: 866367-98-8
(E)-(2S,4S,8S)-10-{(4R,5S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2,4,6,8-tetramethyl-dec-6-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: (-)-(Ipc)2BOTf; Et₃N / CH₂Cl₂ / 3 h / 0 °C

1.2: 70 percent / CH₂Cl₂ / 1 h / 0 °C

2.1: Me₄N(OAc)3BH; AcOH / acetonitrile / -20 °C

3.1: 78 mg / pyridinium p-toluenesulfonate / CH₂Cl₂ / 3 h

4.1: 82 percent / H₂; W-2 Raney nickel / ethanol / 20 °C

With W-2 Raney nickel; hydrogen; pyridinium p-toluenesulfonate; acetic acid; (+)-diisopinocampheylborane trifluoromethanesulfonate; triethylamine; tetramethylammonium triacetoxyborohydride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ol051512r