(S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

Base Information

Chemical Name:(S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea
CAS No.:1620289-87-3
Molecular Formula:C₂₃H₂₂N₄O₃
Molecular Weight:402.453
Hs Code.:

Synonyms:(S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

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Chemical Property of (S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

Chemical Property:

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Technology Process of (S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

There total 6 articles about (S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620289-83-9
1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

: 1620289-85-1
(R)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

: 1620289-87-3
(S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

Guidance literature:: With LUX AMYLOSE-2 AXIA PACKED; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 20281-39-4
2-(allyloxy)-1,1'-biphenyl

: 1620289-85-1
(R)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

: 1620289-87-3
(S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

1.2: 36.5 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 20 °C

3.1: dimethyl sulfoxide / 16 h / 20 °C

4.1: LUX AMYLOSE-2 AXIA PACKED / ethanol; hexane / Resolution of racemate

With hydrogenchloride; N-chloro-succinimide; In 1,4-dioxane; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 90-43-7,287950-96-3
2-Phenylphenol

: 1620289-85-1
(R)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

: 1620289-87-3
(S)-1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyridin-4-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 36.5 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: dimethyl sulfoxide / 16 h / 20 °C

5.1: LUX AMYLOSE-2 AXIA PACKED / ethanol; hexane / Resolution of racemate

With hydrogenchloride; N-chloro-succinimide; potassium carbonate; In 1,4-dioxane; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;