rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

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Chemical Name:rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate
CAS No.:1417736-94-7
Molecular Formula:C₁₉H₂₀N₄O₄
Molecular Weight:368.392
Hs Code.:

Synonyms:rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

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Chemical Property of rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

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Technology Process of rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

There total 4 articles about rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603122-41-4
(3-methoxy-4-(methoxycarbonyl)phenyl)boronic acid

: 1417736-47-0
(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)(cyclopropyl)methanol

: 1417736-94-7
rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; for 40h; Inert atmosphere; Reflux;

Reference yield:

: 939967-94-9
4-aminopyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde

: 1417736-94-7
rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: tetrahydrofuran; diethyl ether / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 40 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 159326-68-8
pyrrolo[2,1-f][1,2,4]triazin-4-amine

: 1417736-94-7
rac-methyl 4-{4-amino-7-[cyclopropyl(hydroxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 30 - 50 °C

1.2: 1 h / 50 °C

1.3: 0.5 h / 20 °C

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

3.1: tetrahydrofuran; diethyl ether / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 40 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;