(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
CAS No.:141613-32-3
Molecular Formula:C₃₈H₃₁BrN₂O₁₀S₂
Molecular Weight:819.708
Hs Code.:

(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Synonyms:(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Chemical Property of (6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Technology Process of (6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 1 articles about (6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 29126-13-4
3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

: 122306-86-9
3-bromo-4,5-diacetoxybenzoyl chloride

: 141613-32-3
(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/jm00092a014

Reference yield:

: 141613-32-3
(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 141613-43-6
diphenylmethyl 7-<2-(2-aminothiazol-4-yl)-2-<<(Z)-1-(tert-butoxycarbonyl)-1-methylethoxy>imino>acetamido>-3-<<(3-bromo-4,5-diacetoxybenzoyl)oxy>methyl>ceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) PCl₅, pyridine, 2.) butane-1,3-diol / 1.) CH₂Cl₂, a.) -20 deg C, 15 min, b.) RT, 1.5 h, 2.) CH₂Cl₂, -20 to RT, 1 h

2: 68 percent / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; 1.3-butanediol; phosphorus pentachloride; In dichloromethane;
DOI:10.1021/jm00092a014

Reference yield:

: 141613-32-3
(6R,7R)-3-(3,4-Diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 141555-09-1
7-{2-(2-aminothiazol-4-yl)-2-[(Z)-(1-carboxy-1-methylethoxy)imino]acetamido}-3-{[(3-bromo-4,5-dihydroxybenzoyl)oxy]methyl}ceph-3-em-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) PCl₅, pyridine, 2.) butane-1,3-diol / 1.) CH₂Cl₂, a.) -20 deg C, 15 min, b.) RT, 1.5 h, 2.) CH₂Cl₂, -20 to RT, 1 h

2: 68 percent / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) TFA, anisole, 2.) NH₄OH / 1.) RT, 1 h

With pyridine; ammonium hydroxide; 1.3-butanediol; phosphorus pentachloride; methoxybenzene; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00092a014