Technology Process of benzyl 4,4-dichloro-1-cyclobutyl-3-oxobutan-2-yl carbamate
There total 5 articles about benzyl 4,4-dichloro-1-cyclobutyl-3-oxobutan-2-yl carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl 4-chloro-1-cyclobutyl-3-oxobutan-2-yl carbamate;
With
sulfuryl dichloride; triethylamine;
In
ethyl acetate;
at 45 ℃;
for 36h;
With
sodium hydroxide;
In
water;
at 0 ℃;
for 0.166667h;
pH=4;
DOI:10.2174/1570178613666160628090059
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 5 °C
1.2: 30.5 h / 0 - 30 °C
1.3: 6 h
2.1: sodium hydrogencarbonate / water; acetonitrile / 1 h / 5 - 10 °C
2.2: 5 h / 5 - 10 °C
3.1: magnesium; iodine; tertiary butyl chloride; ethyl bromide; triethylamine / tetrahydrofuran; toluene / 2 h / 0 - 30 °C / Inert atmosphere
4.1: sulfuryl dichloride / ethyl acetate / 0.5 h / 25 - 30 °C / Inert atmosphere
4.2: 40 h / 45 - 50 °C
With
ethyl bromide; sulfuryl dichloride; tertiary butyl chloride; potassium tert-butylate; iodine; sodium hydrogencarbonate; magnesium; triethylamine;
In
tetrahydrofuran; water; ethyl acetate; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water; acetonitrile / 1 h / 5 - 10 °C
1.2: 5 h / 5 - 10 °C
2.1: magnesium; iodine; tertiary butyl chloride; ethyl bromide; triethylamine / tetrahydrofuran; toluene / 2 h / 0 - 30 °C / Inert atmosphere
3.1: sulfuryl dichloride / ethyl acetate / 0.5 h / 25 - 30 °C / Inert atmosphere
3.2: 40 h / 45 - 50 °C
With
ethyl bromide; sulfuryl dichloride; tertiary butyl chloride; iodine; sodium hydrogencarbonate; magnesium; triethylamine;
In
tetrahydrofuran; water; ethyl acetate; toluene; acetonitrile;
