((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Base Information

Chemical Name:((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol
CAS No.:1596364-58-7
Molecular Formula:C₂₆H₂₇N₅O₃S
Molecular Weight:489.598
Hs Code.:

Synonyms:((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

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Chemical Property of ((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

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Technology Process of ((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

There total 5 articles about ((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 108-86-1,52753-63-6
bromobenzene

: 1596364-57-6
((3aR,4R,6R,6aS)-6-((2-amino-5-(benzo[d]thiazol-2-yl)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 1596364-58-7
((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield:

: 1596364-49-6
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-((5-iodo-2-(methylthio)pyrimidin-4-yl)amino)cyclopentane-1,2-diol

: 1596364-58-7
((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: methanesulfonic acid / acetone / 18 h / 0 - 20 °C

2: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

4: ammonium hydroxide / 1,4-dioxane; water / 1 h / 80 °C / Sealed tube

5: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide / 1,4-dioxane / 18 h / 100 °C

With ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; sodium phenoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; acetone;

Reference yield:

: 1596364-51-0
((3aR,4R,6R,6aS)-6-((5-iodo-2-(methylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 1596364-58-7
((3aR,4R,6R,6aS)-6-((5-(benzo[d]thiazol-2-yl)-2-(phenylamino)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

3: ammonium hydroxide / 1,4-dioxane; water / 1 h / 80 °C / Sealed tube

4: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide / 1,4-dioxane / 18 h / 100 °C

With ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium phenoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water;