(Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

Base Information

Chemical Name:(Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine
CAS No.:132464-61-0
Molecular Formula:C₂₂H₂₀ClN₅O₂S
Molecular Weight:453.952
Hs Code.:

Synonyms:(Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

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Chemical Property of (Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

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Technology Process of (Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

There total 3 articles about (Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 132464-60-9
4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propynyl}morpholine

: 132464-61-0
(Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

Guidance literature:: With thiophene; hydrogen; palladium on activated charcoal; In ethanol; for 1h; under 760 Torr;
DOI:10.1021/jm00108a031

Reference yield:

: 132464-59-6
4-(2-chlorophenyl)-2-(3-hydroxypropyn-1-yl)-9-methyl-6H-thieno[3,2-f][2,4]triazolo[4,3-a][1,4]diazepine

: 132464-61-0
(Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / MnO₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 75 percent / H₂, thiophene / 5percent Pd/C / ethanol / 1 h / 760 Torr

With thiophene; manganese(IV) oxide; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00108a031

Reference yield:

: 57801-81-7
brotizolam

: 132464-61-0
(Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Et₃N, CuI, palladium acetate / dimethylformamide / 0.25 h / 65 - 70 °C

2: 36 percent / MnO₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 75 percent / H₂, thiophene / 5percent Pd/C / ethanol / 1 h / 760 Torr

With thiophene; manganese(IV) oxide; copper(l) iodide; hydrogen; palladium diacetate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a031