N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Base Information

Chemical Name:N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide
CAS No.:1381970-69-9
Molecular Formula:C₂₂H₂₂FN₇O
Molecular Weight:419.461
Hs Code.:

Synonyms:N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

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Chemical Property of N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

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Technology Process of N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

There total 8 articles about N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381971-92-1
5-fluoro-2-(1H-pyrazol-4-yl)pyridine

: 1381972-02-6
N-ethyl-N-(2-hydroxyethyl)-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

: 1381970-69-9
N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: N-ethyl-N-(2-hydroxyethyl)-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide; With methanesulfonyl chloride; triethylamine; In chloroform; at 20 ℃; for 0.75h; Cooling with ice;

5-fluoro-2-(1H-pyrazol-4-yl)pyridine; With caesium carbonate; In acetonitrile; at 80 ℃; for 1h;

Reference yield:

: 1381971-92-1
5-fluoro-2-(1H-pyrazol-4-yl)pyridine

: C₁₅H₂₀N₄O₄S

: 1381970-69-9
N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 41404-58-4
2-bromo-5-fluoropyridine

: 1381970-69-9
N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 20 - 90 °C

2.1: triethylamine; methanesulfonyl chloride / chloroform / 0.75 h / 20 °C / Cooling with ice

2.2: 1 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; triethylamine; In 1,4-dioxane; chloroform; water; 1.1: |Suzuki-Miyaura Coupling;