5-[(4-Chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole

Base Information

Chemical Name:5-[(4-Chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole
CAS No.:6148-18-1
Molecular Formula:C17H15ClN2O3
Molecular Weight:178.621
Hs Code.:
DSSTox Substance ID:DTXSID60351424
Wikidata:Q82127827
ChEMBL ID:CHEMBL1451837
Mol file:6148-18-1.mol

Synonyms:5-[(4-chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole;352346-54-4;SMR000149894;5-[(4-chlorophenoxy)methyl]-3-(4-methoxybenzyl)-1,2,4-oxadiazole;CBMicro_011799;Oprea1_636794;MLS000595371;CHEMBL1451837;DTXSID60351424;HMS1613L11;HMS2504O16;SMSF0015594;STK075959;AKOS001653954;CB14991;BIM-0011734.P001;F16393;5-(4-Chloro-phenoxymethyl)-3-(4-methoxy-benzyl)-[1,2,4]oxadiazole

Suppliers and Price of 5-[(4-Chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Chloromethyl)quinazoline
10mg
$ 85.00

Crysdot
2-(Chloromethyl)quinazoline 95+%
1g
$ 221.00

Chemenu
2-(Chloromethyl)quinazoline 95%
5g
$ 673.00

Chemenu
2-(Chloromethyl)quinazoline 95%
10g
$ 1061.00

Chemenu
2-(Chloromethyl)quinazoline 95%
1g
$ 224.00

Biosynth Carbosynth
2-(Chloromethyl)quinazoline
500 mg
$ 500.00

Biosynth Carbosynth
2-(Chloromethyl)quinazoline
250 mg
$ 325.00

Biosynth Carbosynth
2-(Chloromethyl)quinazoline
50 mg
$ 150.00

Biosynth Carbosynth
2-(Chloromethyl)quinazoline
1 g
$ 700.00

Biosynth Carbosynth
2-(Chloromethyl)quinazoline
100 mg
$ 200.00

Total 14 raw suppliers

Chemical Property of 5-[(4-Chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole

Chemical Property:

Vapor Pressure:5.19E-10mmHg at 25°C
Boiling Point:509.9°C at 760 mmHg
PKA:1.70±0.39(Predicted)
Flash Point:262.2°C
PSA：57.38000
Density:1.278g/cm³
LogP:3.90140
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:330.0771200
Heavy Atom Count:23
Complexity:345

Purity/Quality:

98% ^*data from raw suppliers

2-(Chloromethyl)quinazoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CC2=NOC(=N2)COC3=CC=C(C=C3)Cl
Uses 2-(Chloromethyl)quinazoline is used as a reactant in the preparation of carboxyflavones as CysLT1 (LTD4) receptor antagonists.

Technology Process of 5-[(4-Chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole

There total 6 articles about 5-[(4-Chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.2%

: 6141-22-6
2-chloro-N-(2-formylphenyl)acetamide

: 6148-18-1
2-chloromethylquinazoline

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 4.5h; Sealed tube;

Reference yield: 25.0%

: 34637-41-7
4-chloro-2-(chloromethyl)quinazoline

: 6148-18-1
2-chloromethylquinazoline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; triethylamine; In ethyl acetate; for 7h; under 760.051 Torr;
DOI:10.1039/c4md00167b

Reference yield:

: 529-23-7
o-aminobenzaldehyde

: 6148-18-1
2-chloromethylquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / benzene / 0.25 h / 5 - 20 °C / Inert atmosphere

2: ammonia / methanol / 4.5 h / 20 °C / Sealed tube

With pyridine; ammonia; In methanol; benzene;