4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

Base Information

Chemical Name:4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester
CAS No.:190387-99-6
Molecular Formula:C₂₈H₃₈F₃N₃O₆
Molecular Weight:569.621
Hs Code.:

4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

Synonyms:4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

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Chemical Property of 4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

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Technology Process of 4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

There total 1 articles about 4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105080-14-6
E-(4-Ethoxycarbonyl)benzenepropenoic acid

: (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-amide

: 190387-99-6
4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

Guidance literature:: With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1.) THF, 2.) THF, RT, 18 h;
DOI:10.1021/jm960819g

Reference yield: 65.0%

: 190387-99-6
4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

: 4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

Guidance literature:: With chromium(VI) oxide; diatomaceous earth; In dichloromethane; for 2.5h; Ambient temperature;
DOI:10.1021/jm960819g

Reference yield:

: 190387-99-6
4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid ethyl ester

: 4-((E)-2-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-vinyl)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / CrO₃, diatomaceous earth / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 73 percent / 1 N aq. NaOH / methanol / 18 h / Ambient temperature

With chromium(VI) oxide; diatomaceous earth; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm960819g