(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Name:(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:100206-65-3
Molecular Formula:C₃₂H₃₅Cl₂N₅O₁₁S₂
Molecular Weight:800.695
Hs Code.:

(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Synonyms:(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 4 articles about (6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 100206-64-2
^tboc-β-chloro-L-alanyl-β-chloro-L-alanine

: 100206-63-1
(6R,7R)-3-Iodomethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 100206-65-3
(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/ja00267a045

Reference yield:

: 41625-53-0
p-nitrobenzyl 7β-(2-thienylacetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate

: 100206-65-3
(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TMSI / CH₂Cl₂

2: 62 percent / NaHCO₃ / dimethylformamide / 3 h / Ambient temperature

With trimethylsilyl iodide; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00267a045

Reference yield:

: 100206-68-6
1-(2-Diazo-ethyl)-4-nitro-benzene

: 100206-65-3
(6R,7R)-3-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-chloro-propionylamino)-3-chloro-propionyloxymethyl]-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate

2: TMSI / CH₂Cl₂

3: 62 percent / NaHCO₃ / dimethylformamide / 3 h / Ambient temperature

With trimethylsilyl iodide; sodium hydrogencarbonate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00267a045