ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

Base Information

Chemical Name:ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate
CAS No.:1039068-11-5
Molecular Formula:C₂₁H₂₃ClFN₃O₅S
Molecular Weight:483.948
Hs Code.:

Synonyms:ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

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Chemical Property of ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

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Technology Process of ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

There total 2 articles about ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 919354-21-5
N-(benzylsulfonyl)piperidine-4-carboxamide

: 82671-03-2
ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate

: 1039068-11-5
ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 90 ℃; for 19h;

Reference yield:

: 1039068-11-5
ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

Guidance literature:

Reference yield: 43.0%

: 1039068-11-5
ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate

: 5188-07-8
sodium thiomethoxide

: 1039068-09-1
ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-fluoro-2-(methylthio)nicotinate

Guidance literature:: ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-2-chloro-5-fluoronicotinate; sodium thiomethoxide; In 1-methyl-pyrrolidin-2-one; at 20 - 120 ℃; for 48h; Microwave irradiation;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; water;