Technology Process of N5-<2,3,5-tri-O-acetyl-β-D-ribofuranos-1-yl>-4-benzyl-1,2,5-thiazolidin-3-one 1,1-dioxide
There total 6 articles about N5-<2,3,5-tri-O-acetyl-β-D-ribofuranos-1-yl>-4-benzyl-1,2,5-thiazolidin-3-one 1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium on activated charcoal;
In
ethanol;
at 60 ℃;
for 0.75h;
DOI:10.1016/0040-4020(95)00932-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2.) Et3N
2: 95 percent / diethylazodicarboxylate, PPh3 / tetrahydrofuran / 0.75 h / 5 °C
3: 92 percent / TFA / CH2Cl2 / 2 h
4: 82 percent / 4N NaOH / ethanol / 1 h
5: 1.) HMDS, 2.) SnCl4 / 1.) reflux, 24 h, 2.) CH3CN, 60 deg C, 24 h
6: 68 percent / ammonium formate / 5percent Pd/C / ethanol / 0.75 h / 60 °C
With
sodium hydroxide; ammonium formate; tin(IV) chloride; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/0040-4020(95)00932-9
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / diethylazodicarboxylate, PPh3 / tetrahydrofuran / 0.75 h / 5 °C
2: 92 percent / TFA / CH2Cl2 / 2 h
3: 82 percent / 4N NaOH / ethanol / 1 h
4: 1.) HMDS, 2.) SnCl4 / 1.) reflux, 24 h, 2.) CH3CN, 60 deg C, 24 h
5: 68 percent / ammonium formate / 5percent Pd/C / ethanol / 0.75 h / 60 °C
With
sodium hydroxide; ammonium formate; tin(IV) chloride; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/0040-4020(95)00932-9
