methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

Base Information

Chemical Name:methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate
CAS No.:1202474-70-1
Molecular Formula:C₂₂H₂₂N₂O₆
Molecular Weight:410.426
Hs Code.:

Synonyms:methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

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Chemical Property of methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

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Technology Process of methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

There total 4 articles about methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C₁₁H₁₁NO₃: 1202474-62-1
C₁₁H₁₁NO₃

methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate: 1202474-70-1
methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

Guidance literature:: With gold(III) chloride; silver trifluoromethanesulfonate; In acetonitrile; at 25 ℃; Inert atmosphere; Reflux;
DOI:10.1055/s-0029-1217961

Reference yield:

: 41608-64-4
methyl 3-methoxy-4-aminobenzoate

methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate: 1202474-70-1
methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: [bis(pyridine)iodine]⁺ tetrafluoroborate; tetrafluoroboric acid / dichloromethane / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 6 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: Au₂(BIPHEP)(NTf₂)₂ / 1,2-dichloro-ethane / 6 h / 25 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrafluoroboric acid; Au₂(BIPHEP)(NTf₂)₂; tetrabutyl ammonium fluoride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Barluenga Lodination / 2: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0035-1561305

Reference yield:

: 180624-21-9
methyl 4-amino-3-methoxy-5-[2-(trimethylsilyl)ethynyl]benzoate

methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate: 1202474-70-1
methyl 2-(2-amino-3-methoxy-5-methoxycarbonylphenyl)-8-methoxy-4-methylquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: Au₂(BIPHEP)(NTf₂)₂ / 1,2-dichloro-ethane / 6 h / 25 °C / Inert atmosphere

With Au₂(BIPHEP)(NTf₂)₂; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1055/s-0035-1561305