sinalexin

Base Information

• Chemical Name: sinalexin
• CAS No.: 200192-82-1
• Molecular Formula: C10H8N2OS
• Molecular Weight: 204.25
• Mol file: 200192-82-1.mol

Synonyms:

Chemical Property of sinalexin

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Sinalexin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Sinalexin is a phytoalexin from white mustard elicited by destruxin B and Alternaria brassicae.

Technology Process of sinalexin

There total 7 articles about sinalexin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-methoxyindoline-2-thione → sinalexin (200192-82-1)

Guidance literature:

N,N-dimethyl-formamide; 1-methoxyindoline-2-thione; With trichlorophosphate; at 40 ℃; for 1h;

With ammonium hydroxide; at 0 ℃;

With pyridine; iodine; Further stages.;

DOI:10.1021/ol015691y

Reference yield:

3-[1-Amino-meth-(E)-ylidene]-1-methoxy-1,3-dihydro-indole-2-thione (922495-15-6) → sinalexin (200192-82-1)

Guidance literature:

With iodine; In pyridine; at 20 ℃; for 1h;

DOI:10.1021/jo0479866

Reference yield:

1-Methoxy-3-[(Z)-2-thioxo-propylimino]-1,3-dihydro-indole-2-thione → sinalexin (200192-82-1)

Guidance literature:

With pyridine; iodine; In ethanol;

DOI:10.1021/ol015691y

upstream raw materials:

N,N-dimethyl-formamide

3-[1-Amino-meth-(E)-ylidene]-1-methoxy-1,3-dihydro-indole-2-thione

1-methoxy-3-aminomethyleneindol-2-one

Refernces

• 1、 Pedras, M. Soledad C.,Zaharia, Irina L.. "Unprecedented vilsmeier formylation: Expedient syntheses of the cruciferous phytoalexins sinalexin and brassilexin and discovery of a new heteroaromatic ring system". . p. 1213 - 1216. Retrieved 2007/10/03.