(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Base Information

Chemical Name:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol
CAS No.:1423044-99-8
Molecular Formula:C₂₇H₃₀ClF₆NO₂
Molecular Weight:549.984
Hs Code.:

Synonyms:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

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Chemical Property of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

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Technology Process of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

There total 4 articles about (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₈ClF₆NO₂

: 1423044-99-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: With sodium cyanoborohydride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1621255-69-3
2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enecarbaldehyde

: 1423044-99-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 1 h

2: sodium cyanoborohydride / dichloromethane / 3 h / 20 °C

With sodium cyanoborohydride; acetic acid; In dichloromethane;

Reference yield:

: 105854-65-7
2-chloro-5,5-dimethylcyclohex-1-enecarbaldehyde

: 1423044-99-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 18 h / 100 °C

2: acetic acid / dichloromethane / 1 h

3: sodium cyanoborohydride / dichloromethane / 3 h / 20 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium cyanoborohydride; sodium carbonate; acetic acid; In 1,2-dimethoxyethane; dichloromethane; water; 1: |Suzuki Coupling;