N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
• CAS No.: 1346447-77-5
• Molecular Formula: C₂₀H₂₂ClN₅O₂S
• Molecular Weight: 431.946

Synonyms:N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Chemical Property of N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

There total 6 articles about N₂-(3-aminobenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(3-nitrobenzyl)pyrimidine-2,4-diamine (1346447-76-4) → N2-(3-aminobenzyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1346447-77-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; for 2h;

Reference yield:

1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) → N2-(3-aminobenzyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1346447-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

1.2: 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

3.1: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-(isopropyl sulfanyl)nitrobenzene (70415-85-9) → N2-(3-aminobenzyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1346447-77-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

5.1: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; platinum(IV) oxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

ortho-nitrofluorobenzene

2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine

2-(isopropyl sulfanyl)nitrobenzene

1-amino-2-(isopropylsulphonyl)benzene

Downstream raw materials:

N-(3-(((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)methyl)phenyl)acrylamide

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