2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol

Base Information

• Chemical Name: 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol
• CAS No.: 1350325-27-7
• Molecular Formula: C₁₅H₁₁BrClFN₂O
• Molecular Weight: 372.597

Synonyms:2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol

Chemical Property of 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol

There total 2 articles about 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)(2,2,2-2H3)ethyl]-1H-pyrrolo[2,3-b]pyridine (1350325-19-7) → 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H3)ethyl]-3-chloro-4-fluorophenol (1350325-27-7)

Guidance literature:

5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)(2,2,2-2H₃)ethyl]-1H-pyrrolo[2,3-b]pyridine; With boron tribromide; In dichloromethane; at -78 - 20 ℃;

With methanol; ammonia; In dichloromethane; at 0 ℃;

Reference yield:

racemic 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)(2,2,2-2H3)ethyl]-1H-pyrrolo[2,3-b]pyridine (1350325-20-0) → 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H3)ethyl]-3-chloro-4-fluorophenol (1350325-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ChiralPak IA / carbon dioxide; methanol / Resolution of racemate

2.1: boron tribromide / dichloromethane / -78 - 20 °C

2.2: 0 °C

With boron tribromide; In methanol; dichloromethane; carbon dioxide;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H3)ethyl]-3-chloro-4-fluorophenol (1350325-27-7) → tert-butyl 5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-hydroxyphenyl)(2,2,2-2H3)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (1350325-26-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃;

upstream raw materials:

5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)(2,2,2-2H₃)ethyl]-1H-pyrrolo[2,3-b]pyridine

racemic 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)(2,2,2-2H₃)ethyl]-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

tert-butyl 5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-hydroxyphenyl)(2,2,2-2H₃)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](2,2,2-2H₃)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1350325-27-7 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,2,2-2H₃)ethyl]-3-chloro-4-fluorophenol

Send

Send

Metric Ton KG G Pound L ML

Send

Send