(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

Base Information

Chemical Name:(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine
CAS No.:1351338-67-4
Molecular Formula:C₂₅H₃₁F₂N₇O₂
Molecular Weight:499.564
Hs Code.:

Synonyms:(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

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Chemical Property of (3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

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Technology Process of (3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

There total 4 articles about (3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351341-84-8
((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester

: 1351338-67-4
(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

Guidance literature:: ((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.33333h;

With ammonium hydroxide; In methanol; dichloromethane;

Reference yield:

: 51075-37-7
4-hydroxypiperidine-1-carbonitrile

: 1351338-67-4
(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) chloride / ethanol / 2 h / 20 °C

1.2: 16 h / 50 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / 20 °C

2.2: 17.5 h / 20 - 30 °C

2.3: 16 h / 35 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 16 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 1.33 h / 20 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; zinc(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; mineral oil;

Reference yield:

: 832714-37-1
1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ol

: 1351338-67-4
(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yloxymethyl]pyrimidin-2-yl}pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / 20 °C

1.2: 17.5 h / 20 - 30 °C

1.3: 16 h / 35 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 16 h / 70 °C

3.1: trifluoroacetic acid / dichloromethane / 1.33 h / 20 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; mineral oil;