ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1359669-82-1
Molecular Formula:C₃₁H₃₆O₅
Molecular Weight:488.624
Hs Code.:

Synonyms:ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

There total 8 articles about ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 805250-51-5
[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methanol

: 1359668-99-7
ethyl 5-Hydroxy-2,3-dihydro-1H-indene-2-carboxylate

: 1359669-82-1
ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm2012968

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 1359669-82-1
ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / toluene; mineral oil / 0.5 h / 20 - 120 °C

1.2: 3 h / 120 °C

2.1: triethylsilane; trifluoroacetic acid / 4 h / 0 - 20 °C

3.1: aluminum (III) chloride; Octanethiol / dichloromethane / 3.5 h / 0 - 20 °C

4.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

With triethylsilane; aluminum (III) chloride; Octanethiol; tributylphosphine; sodium hydride; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; In dichloromethane; toluene; mineral oil; 4.1: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 7463-51-6
4-bromo-3,5-dimethylphenol

: 1359669-82-1
ethyl 5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / ethanol; toluene / 70 - 80 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; potassium carbonate; caesium carbonate; potassium iodide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling / 4.1: Mitsunobu reaction;
DOI:10.1021/jm2012968