4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

Base Information

Chemical Name:4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine
CAS No.:928655-62-3
Molecular Formula:C₃₀H₃₂N₂O₆
Molecular Weight:516.594
Hs Code.:

Synonyms:4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

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Chemical Property of 4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

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Technology Process of 4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

There total 4 articles about 4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874183-98-9
4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}-N-[(1,1-dimethylethoxy)carbonyl]phenylalanine

: 928655-62-3
4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/hlca.200690275

Reference yield:

: 874183-97-8
6,7-dimethoxy-3-(4-methoxyphenyl)-1-(prop-2-en-1-yl)-1H-quinolin-2-one

: 928655-62-3
4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Ph₃P; Cs₂CO₃ / Pd(OAc)2 / H₂O; dimethylformamide / 10 h / 80 °C / microwave irradiation

2: 92 percent / H₂ / Pd/C / methanol / 16 h / 750.08 Torr

3: CF₃COOH; (i-Pr)3SiH / CH₂Cl₂ / 2 h / 20 °C

With chlorotriisopropylsilane; hydrogen; caesium carbonate; triphenylphosphine; trifluoroacetic acid; palladium diacetate; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Heck cross-coupling;
DOI:10.1002/hlca.200690275

Reference yield:

: 874184-03-9
4-{(1E)-3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]prop-1-enyl}-N-[(1,1-dimethylethoxy)carbonyl]phenylalanine

: 928655-62-3
4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / Pd/C / methanol / 16 h / 750.08 Torr

2: CF₃COOH; (i-Pr)3SiH / CH₂Cl₂ / 2 h / 20 °C

With chlorotriisopropylsilane; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/hlca.200690275